The Centralis and Teraplex Wars takes place in the year 895. Rama Tibal resurfaces after hundreds of years in exile on Earth in an attempt to besiege the wolf capitol of Centralis. Eventually he is stopped by the now adult Elite. It is during this war that Alpha Akaelae, the last of the original twelve squid-tampered Wolves, dies. He will then be succeeded by Kela Akaelae.
The Plague ravaged the Fox population that was tightly packed in the cities in the year 894, starting with the poor in the worst conditions. Those who had aerial means of escape, did. Those who could STEAL transport, did, often manning ships far under capacity - and many city refugees joined Rama. 
Here be a list of where the war is referenced in the comic.
- Sink or Swim, strip 171
- Sink or Swim, strips 206-214
- Cyantian Timeline - For an overview of the events leading to the wars.